abstract：:We considered the possibility that the greater the distance between an immune receptor V and J, the more likely the V usage. Such a hypothesis is supported by results from mouse experiments. And, such a hypothesis is consistent with the fundamental nature of recombination and genomic distance: the further the distance...

journal_title：Molecular immunology

authors： Pakasticali N,Gill T,Chobrutskiy BI,Tong WL,Ramsamooj M,Blanck G

更新日期：2019-12-01 00:00:00

abstract：:Keratin is a cytoskeletal protein that constitutes the intermediate filament. Its distribution is restricted to epithelial tissues in mammals, but is wider in fish. An interesting feature of fish keratin is that it is abundant in the cutaneous mucus. However, the biological function of keratin in the mucus has not bee...

journal_title：Molecular immunology

authors： Shibuya K,Tsutsui S,Nakamura O

更新日期：2019-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are now recognized as important regulators of all cellular processes, including immune function and cancer survival. These evolutionary preserved, single-stranded, non-coding RNA molecules mediate important functional effects primarily through post-transcriptional regulation of protein expression. M...

journal_title：Molecular immunology

authors： Saultz JN,Freud AG,Mundy-Bosse BL

更新日期：2019-11-01 00:00:00

abstract：:Human CD63 has been reported to play a role either as an inhibitor or as a co-stimulator of T- cell responses, although the mechanism of this is unclear. In this study, an anti-human CD63 monoclonal antibody (mAb) COS3A was used to monitor the role of CD63 in T-cell activation. MAb COS3A could inhibit CD3-mediated T-c...

journal_title：Molecular immunology

authors： Wansook S,Mahasongkram K,Chruekamlow N,Pata S,Kasinrerk W,Khunkaewla P

更新日期：2019-10-01 00:00:00

abstract：:Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregul...

journal_title：Molecular immunology

authors： Ajjan RA,Schroeder V

更新日期：2019-10-01 00:00:00

abstract：:Complement defects are associated with an enhanced risk of a broad spectrum of infectious as well as systemic or local inflammatory and thrombotic disorders. Inherited complement deficiencies have been described for virtually all complement components but can be mimicked by autoantibodies, interfering with the activit...

journal_title：Molecular immunology

authors： Schröder-Braunstein J,Kirschfink M

更新日期：2019-10-01 00:00:00

abstract：:The Fc region of IgG antibodies is crucial for binding to Fc receptors expressed on the surfaces of various immune leukocytes and eliciting therapeutic effector functions such as clearance of antibody-opsonized tumor cells. Despite abrogated Fc gamma receptor (FcγR) binding and therapeutic effector function in the abs...

journal_title：Molecular immunology

authors： Yoon HW,Jo M,Ko S,Kwon HS,Lim CS,Ko BJ,Lee JC,Jung ST

更新日期：2019-10-01 00:00:00

abstract：:Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus causing diarrhea and intestinal damage in nursing piglets. Previous work showed that PDCoV infection inhibits type I interferon (IFN) production. To further identify and characterize the PDCoV-encoded IFN antagonists will broaden our understanding of it...

journal_title：Molecular immunology

authors： Liu X,Fang P,Fang L,Hong Y,Zhu X,Wang D,Peng G,Xiao S

更新日期：2019-10-01 00:00:00

abstract：:Mangiferin is the major bioactive ingredient in the leaves of Mangifera indica L., Aqueous extract of such leaves have been traditionally used as an indigenous remedy for respiratory diseases including cough and asthma in Traditional Chinese Medicine. Mangiferin was shown to exert its anti-asthmatic effect by modulati...

journal_title：Molecular immunology

authors： Yun C,Chang M,Hou G,Lan T,Yuan H,Su Z,Zhu D,Liang W,Li Q,Zhu H,Zhang J,Lu Y,Deng J,Guo H

更新日期：2019-10-01 00:00:00

abstract：AIM:To study the role of complement receptor 1 (CR1) for binding of Escherichia coli (E. coli) to erythrocytes, for leukocyte phagocytosis, oxidative burst and complement activation in human whole blood from a CR1 deficient (CR1D) patient and healthy controls with low, medium and high CR1 numbers. METHODS:Alexa-labell...

journal_title：Molecular immunology

authors： Brekke OL,Christiansen D,Kisserli A,Fure H,Dahl JA,Donvito B,Reveil B,Ludviksen JK,Tabary T,Mollnes TE,Cohen JHM

更新日期：2019-10-01 00:00:00

abstract：:CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they recognize peptides of about 8-to-10 amino acids that generally result from the degradation of cellular proteins by the proteasome. Until a decade ago, these peptides were thought to solely correspond to linear fragments ...

journal_title：Molecular immunology

authors： Vigneron N,Stroobant V,Ferrari V,Abi Habib J,Van den Eynde BJ

更新日期：2019-09-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) has anti-inflammatory, anti-oxidant and immune-regulating properties, while the mechanism of DHEA actions remains unclear. The present study aims to investigate the effect and possible mechanism of DHEA on immune function of mice in vivo and in vitro. In vivo, a lipopolysaccharide (LPS)-i...

journal_title：Molecular immunology

authors： Cao J,Yu L,Zhao J,Ma H

更新日期：2019-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of motor and cognitive impairment in young adults. It is associated with high mortality rates and very few effective treatment options. Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] is an commercially available inhibitor of Phosphatase and tensin homolog (PTEN). Previ...

journal_title：Molecular immunology

authors： Liu R,Liao XY,Tang JC,Pan MX,Chen SF,Lu PX,Lu LJ,Zhang ZF,Zou YY,Bu LH,Qin XP,Wan Q

更新日期：2019-08-01 00:00:00

abstract：:ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

journal_title：Molecular immunology

authors： Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

更新日期：2019-08-01 00:00:00

abstract：:Neutrophil migration is essential for battling against infections but also drives chronic inflammation. Since primary neutrophils are terminally differentiated and not genetically tractable, leukemia cells such as HL-60 are differentiated into neutrophil-like cells to study mechanisms underlying neutrophil migration. ...

journal_title：Molecular immunology

authors： Hsu AY,Liu S,Syahirah R,Brasseale KA,Wan J,Deng Q

更新日期：2019-08-01 00:00:00

abstract：:Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizing cattle antibodies...

journal_title：Molecular immunology

authors： Ren J,Nettleship JE,Harris G,Mwangi W,Rhaman N,Grant C,Kotecha A,Fry E,Charleston B,Stuart DI,Hammond J,Owens RJ

更新日期：2019-08-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. Typhimurium) changes the structure of its lipopolysaccharide (LPS) in response to the environment. The two main LPS variants found in S. Typhimurium correspond to LPS with a hepta-acylated lipid A (LPS 430) and LPS with modified phosphate groups on its lipid A (LPS 435). We ...

journal_title：Molecular immunology

authors： Aldapa-Vega G,Moreno-Eutimio MA,Berlanga-Taylor AJ,Jiménez-Uribe AP,Nieto-Velazquez G,López-Ortega O,Mancilla-Herrera I,Cortés-Malagón EM,Gunn JS,Isibasi A,Wong-Baeza I,López-Macías C,Pastelin-Palacios R

更新日期：2019-07-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:Endodontic infection is a widespread oral problem. DNA methylation is a key epigenetic modification that plays important roles in various inflammatory responses, but its role in dental pulp inflammation is poorly understood. In this study, we assessed the expression of DNA methyltransferases (DNMTs) in human dental pul...

journal_title：Molecular immunology

authors： Mo Z,Li Q,Cai L,Zhan M,Xu Q

更新日期：2019-07-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has been a large effort to dissect the mechanisms required for GI homeostasis, with a major focus on different immune cell populations and the cytokines that they produce. In contrast to T-help...

journal_title：Molecular immunology

authors： Fung KY,Nguyen PM,Putoczki T

更新日期：2019-06-01 00:00:00

abstract：:The myobacterial factors and the associated mechanism by which Mycobacterium tuberculosis (Mtb) evades the host immune surveillance system remain widely unexplored. Here, we found that overexpressing Rv1016c, a mannosylated protein of M. tuberculosis in BCG (rBCG-Rv1016c) led to increased virulence of the recombined B...

journal_title：Molecular immunology

authors： Su H,Peng B,Zhang Z,Liu Z,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:The maintenance of intestinal tissue homeostasis is vital for the resistance against inflammatory bowel diseases (IBDs). Necroptosis is identified as an alternative mode of regulated cell death, which plays a pivotal role in tissue homeostasis. Thus, the roles of RIP3-mediated necroptosis in intestinal inflammation ha...

journal_title：Molecular immunology

authors： Zhang J,Qin D,Yang YJ,Hu GQ,Qin XX,Du CT,Chen W

更新日期：2019-03-01 00:00:00

abstract：:High glucose- induced endothelial dysregulation has been recognized as an initiation of vascular complications in Type 2 diabetes mellitus (T2DM). Anagliptin is a novel licensed dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of T2DM. The effects of anagliptin in high glucose- induced endothelial dysfunctio...

journal_title：Molecular immunology

authors： Jiang T,Jiang D,Zhang L,Ding M,Zhou H

更新日期：2019-03-01 00:00:00

abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...

journal_title：Molecular immunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Alshammari MA,Attia SM

更新日期：2019-02-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) mainly caused by Leishmania braziliensis is a chronic inflammatory disease widely spread in Brazil. Genetic variant strains of this parasite have been associated with atypical clinical manifestations of CL in an endemic area in Brazil. Furthermore, these strains have presented distinct bio...

journal_title：Molecular immunology

authors： Rêgo FD,Fradico JRB,Teixeira-Carvalho A,Gontijo CMF

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Using multiplex microarray-based component resolved diagnosis (CRD) to investigate the allergen sensitization profile of allergic asthma patients in southern China. METHOD:Serum samples from 57 polysensitized mite allergic asthmatic patients in a tertiary referral centre of southern China were tested with mu...

journal_title：Molecular immunology

authors： Hu H,Luo W,Wu Z,Cai C,Huang H,Sun B

更新日期：2019-01-01 00:00:00

abstract：:Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate antibodies at the ...

journal_title：Molecular immunology

authors： Eyes TJ,Austerberry JI,Dearman RJ,Johannissen LO,Kimber I,Smith N,Thistlethwaite A,Derrick JP

更新日期：2019-01-01 00:00:00

abstract：:Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune an...

journal_title：Molecular immunology

authors： Schmidt T,Luebbe J,Paust HJ,Panzer U

更新日期：2018-12-01 00:00:00

abstract：:Bothropasin is a hemorrhagic snake venom metalloproteinase (SVMP) from Bothrops jararaca venom, the snake responsible for most bites in Southeastern Brazil. SVMPs, such as bothropasin, are involved in the main bothropic envenoming symptoms, which include hemorrhage, inflammation, necrosis and blood coagulation deficie...

journal_title：Molecular immunology

authors： Molina Molina DA,Guerra-Duarte C,Naves de Souza DL,Costal-Oliveira F,Ávila GR,Soccol VT,Machado-de-Ávila RA,Chávez-Olórtegui C

更新日期：2018-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the...

journal_title：Molecular immunology

authors： Kjældgaard AL,Pilely K,Olsen KS,Pedersen SW,Lauritsen AØ,Møller K,Garred P

更新日期：2018-10-01 00:00:00

abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

journal_title：Molecular immunology

authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

更新日期：2018-09-01 00:00:00

abstract：:Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or ...

journal_title：Molecular immunology

authors： Fu L,Guo Y,Sun Y,Dong Y,Wu J,Yu B,Zhang H,Yu X,Wu H,Kong W

更新日期：2018-09-01 00:00:00

abstract：:Interleukin 1 receptor-associated kinase 4 (IRAK4) is a key factor in TLR-mediated host immune function. In this study, an IRAK4 homologue molecule was identified from Apostichopus japonicus (designated as AjIRAK4) by RACE approach. The full-length cDNA of AjIRAK4 was of 2024 bp containing an open reading frame of 131...

journal_title：Molecular immunology

authors： Cui Y,Jiang L,Xing R,Wang Z,Wang Z,Shao Y,Zhang W,Zhao X,Li C

更新日期：2018-09-01 00:00:00

abstract：:The effectiveness of immunotherapy targeting the immune checkpoint PD-L1/PD-1 pathway highlights importance of elucidating the regulatory mechanisms of PD-L1 expression in cancer cells. Previous studies demonstrate that oncogene MYC up-regulates PD-L1 expression in lymphomas. In the present study, we investigated the ...

journal_title：Molecular immunology

authors： Zou J,Zhuang M,Yu X,Li N,Mao R,Wang Z,Wang J,Wang X,Zhou H,Zhang L,Shi Y

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) or atopic eczema is a skin disease characterized with itching, increased serum level of immunoglobulin E, and peripheral eosinophilia. Thymoquinone (TQ) is an important ingredient of Nigella sativa seeds having antioxidant and anti-inflammatory effects. OBJECTIVE:Present study investi...

journal_title：Molecular immunology

authors： Aslam H,Shahzad M,Shabbir A,Irshad S

更新日期：2018-09-01 00:00:00

abstract：:Excessive production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) plays a key role in the pathophysiological development of osteoarthritis (OA). Orexin A is an important peptide of hypothalamic origin, which has displayed its multiple biological functions in several chronic diseases via activation of i...

journal_title：Molecular immunology

authors： Wang D,Ren H,Li C,Liu F,Wang G,Shi F,Sun Y

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in antigen presentation, which is an essential step for the induction of antigen-specific adaptive immunity. Inactivated bacterial whole cell vaccines have been widely used to prevent many bacterial infections because they elicit good immunogenicity due to the presence of v...

journal_title：Molecular immunology

authors： Kim HY,Kim SK,Seo HS,Jeong S,Ahn KB,Yun CH,Han SH

更新日期：2018-09-01 00:00:00

abstract：:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the ep...

journal_title：Molecular immunology

authors： Tsagaratou A

更新日期：2018-09-01 00:00:00

abstract：:Most studies of the immune responses in allergic rhinitis have focused on IgE antibodies to mixtures of allergenic proteins. Based on our previous studies of the major mountain cedar allergen Jun a 1, we sought to describe a broader assessment of the humoral immune responses to a single, dominant allergen, in three gr...

journal_title：Molecular immunology

authors： Goldblum RM,Madagoda-Desilva RS,Zhang Y,van Bavel J,Midoro-Horiuti T

更新日期：2018-09-01 00:00:00

abstract：:Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infection...

journal_title：Molecular immunology

authors： Caraballo L,Coronado S

更新日期：2018-08-01 00:00:00